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Originally Posted by The Reaper Man@Cult Labs  Glad you're here Billy.You're just what I need! 
Now please tell me WTF was going on in Lost Highway-was it all in his head?  |
Honestly? I really couldn't tell you but I'm happy not to know and just to let the film wash over me, same with MD and most of the Lynch back catalogue and Donnie Darko too for that matter.
Though there are plenty of sites that try to decipher the film. Here is one such interpretation:
Lost Highway: Explained 