I always thought Lost Highway was based around "An Occurence at Own Creek Bridge" which is about a guy dreaming of escaping from prison and going home as he's being executed.
Except, as this is a Lynch, the dream is of a new life, with all the opposites of Fred's life, he's young, has better sex (or sex at all!), his life is dangerous etc, whilst the real Fred's life was boring.
I remember at the time Lynch talking about Moebian strips, where if a loop is cut and reattached upside down, the surface would carry on one one side until reaching the point of reattachment and instantly flip to the other side and carry on until reaching the split again.
Eraserhead on the other hand is a pretty simple story about the fear of not coping with growing up, love, sex and children, but obviously with a ton of surrealism in there.
That's just my interpretation of it though!
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