Like Hawk i'm not sure where his mainstream career began. eXistenZ (1999) perhaps? It's actually a film i have little love for if i'm honest.
His follow up Spider (2002) starring Ralph Fiennes is excellent. A disturbing tale of extreme schizophrenia.
A History of Violence (2005) and Eastern Promises (2007) are both great little thrillers, allowing his go-to actor of choice, Viggo Mortensen, a respite from running around with Hobbits.
His standout film for me of the last ten years was A Dangerous Method (2011). A superbly acted period piece about the birth of psychoanalysis. Mortensen (again) and Michael Fassbender are both delightful as Sigmund Freud and Carl Jung. Keira Knightly gives a career best (In my opinion) performance as Sabina Spielrein. A hospitalized patient who the doctors come into conflict over both personally and medically.
I haven't seen Cosmopolis yet.
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