Mastermind isn't really
that high-brow, specialist subjects in the past have included things like Doctor Who, Blackadder, Father Ted, Quentin Tarantino, The Sci-Fi novels of Iain Banks, The life of John Lennon, Thunderbirds, The history of Westerns (films).
Anything can be a specialist subject really, you either know it or you don't, and I'm sure that just as few people know about the 1992-1993 new wave of Norwegian Black Metal as they do the intricacies of Wagner's life and times.